Luteolin木犀草素的抗炎、抗氧化、抗腫瘤活性機(jī)制及應(yīng)用

Luteolin（木犀草素，AbMole，M4589）是一種廣泛存在于植物中的黃酮類化合物，具有多種生物活性，包括抑制炎癥、抗氧化、抑制腫瘤生長(zhǎng)以及抗菌等作用。在細(xì)胞實(shí)驗(yàn)中，Luteolin在20-40 µM濃度范圍內(nèi)顯著抑制肺癌A549細(xì)胞的遷移、侵襲以及偽足形成，且對(duì)非癌性MRC-5細(xì)胞無毒性作用[1]。此外，Luteolin（CAS No.：491-70-3）在40 µM濃度下可顯著減少HT29細(xì)胞的存活率，并通過增加活性氧（ROS）水平誘導(dǎo)細(xì)胞凋亡[2]。Luteolin在黑色素瘤研究中，體外細(xì)胞模型和體內(nèi)小鼠模型均表現(xiàn)出抑制腫瘤生長(zhǎng)的效果，其作用機(jī)制涉及基因組水平的調(diào)控[3]。

Luteolin在肺癌小鼠模型中，通過增強(qiáng)T細(xì)胞介導(dǎo)的殺傷途徑促進(jìn)腫瘤細(xì)胞凋亡，顯著抑制腫瘤生長(zhǎng)[4]。Luteolin在抗菌研究中，對(duì)金黃色葡萄球菌（包括耐甲氧西林金黃色葡萄球菌MRSA）表現(xiàn)出抑制作用[5, 6]。在神經(jīng)保護(hù)研究中，Luteolin可顯著預(yù)防β-淀粉樣蛋白（Aβ）誘導(dǎo)的PC-12細(xì)胞凋亡，并抑制細(xì)胞活力下降[7]。此外，Luteolin在α-葡萄糖苷酶抑制實(shí)驗(yàn)中表現(xiàn)出非競(jìng)爭(zhēng)性抑制機(jī)制，其IC50值約為32 µM，顯著低于阿卡波糖（815 µM）[8]。Luteolin在昆蟲研究中，在0.1 mg/mL濃度下可顯著縮短成蟲壽命并降低繁殖力[9]。這些研究結(jié)果表明，Luteolin（木犀草素，AbMole，M4589）在多種細(xì)胞（如A549、HT29、PC-12）和動(dòng)物模型（如小鼠）中具有廣泛的科研應(yīng)用潛力，其作用機(jī)制涉及多種信號(hào)通路和分子靶點(diǎn)。

參考文獻(xiàn)及鳴謝
[1] Masraksa, W.; Tanasawet, S.; Hutamekalin, P.; et al. Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway. Nutrition research and practice 2020, 14 (2), 127-133.
[2] Yang, H.; Liu, B. F.; Xie, F. J.; et al. Luteolin induces mitochondrial apoptosis in HT29 cells by inhibiting the Nrf2/ARE signaling pathway. Experimental and therapeutic medicine 2020, 19 (3), 2179-2187.
[3] Schomberg, J.; Wang, Z.; Farhat, A.; et al. Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS. Biochemical pharmacology 2020, 177, 114025.
[4] Li, X.; Bai, Y.; Zhou, J.; et al. Luteolin targets peroxiredoxin 2 to augment T-cell-mediated cytotoxicity and suppress lung adenocarcinoma progression. European journal of pharmacology 2025, 1004, 177984.
[5] Sun, Y.; Sun, F.; Feng, W.; et al. Luteolin Inhibits the Biofilm Formation and Cytotoxicity of Methicillin-Resistant Staphylococcus aureus via Decreasing Bacterial Toxin Synthesis. Evidence-based complementary and alternative medicine : eCAM 2022, 2022, 4476339.
[6] Zhang, D.; Gao, X.; Song, X.; et al. Luteolin Showed a Resistance Elimination Effect on Gentamicin by Decreasing MATE mRNA Expression in Trueperella pyogenes. Microbial drug resistance (Larchmont, N.Y.) 2019, 25 (4), 619-626.
[7] Wang, H. R.; Pei, S. Y.; Fan, D. X.; et al. Luteolin Protects Pheochromocytoma (PC-12) Cells against Abeta (25-35)-Induced Cell Apoptosis through the ER/ERK/MAPK Signalling Pathway. Evidence-based complementary and alternative medicine : eCAM 2020, 2020, 2861978.
[8] Djeujo, F. M.; Ragazzi, E.; Urettini, M.; et al. Magnolol and Luteolin Inhibition of alpha-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies. Pharmaceuticals (Basel, Switzerland) 2022, 15 (2).
[9] Ren, X.; Li, M.; Zheng, L.; et al. Luteolin Effects on Mortality, Development and Population Parameters of Frankliniella occidentalis (Pergande). Insects 2025, 16 (12).